Asian Journal of Pharmacy and Technology

Abdul Saleem Mohammad ¹, Swetha Devidi ², Nikhat Fatima ¹, Humera Badar ¹, Syeda Saba Sulthana ¹, Mohammad Akthar Sulthana ³, Nuha Rasheed ⁴

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Chemistry, St. Mary’s Pharmacy college, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Vivekananda Group of Institutions (Pharmacy Department), Near Ramoji Film City, Ranga Reddy District, Hyderabad, Telangana, 501511, IN
4 Department of Pharmaceutics, Nizam Institute of Pharmacy, Near Ramoji Film City, Pochampally (Mandal), Deshmukhi Village - 508284, Nalgonda Dist., Telangana, IN

Abstract

Quality is the primordial intention to any pharmaceutical industry and its products manufactured. The current interest in the pharmaceutical industry is to obtain best quality. Acquainted with a practice that puts us in common and routine convention ensured to deliver a quality that sounds globally in terms of a spoken quality is on the dais of pharmaceutical arena. Validation is the mean of catering enormous benefits to even more than the acceptable quality level which in the global standard scale. Validation is the art of designing and practicing the designed steps alongside with the documentation. Validation and quality assurance will go hand in hand, ensuring the through quality for the products. Process Validation emphasize on process design elements and maintaining process control during commercialization and communicate that process validation is an ongoing program and align process validation activities with product life cycle. Process validation also emphasizes the role of objective measures and statistical tools and analyses and emphasizes knowledge, detection, and control of variability and gives assurance on consistent of quality/productivity throughout life cycle of product additionally a view of validation against the quality assurance, drug development and manufacturing process has been discussed.

Keywords

Quality, Validation, Types of Validation, Process Validation, Protocol, Regulatory Basis, Master Plan.

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Abdul Saleem Mohammad ¹, Nuha Rasheed ², Mohammed Nayeem Uddin ³, Hajera Hafeez ⁴

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmacology, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
4 Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad, Ranga Reddy (Dist)-501504, Telangana, IN

Abstract

The aim of present study confirmed that the SEDDS formulation can be used as a possible alternate to traditional or classical formulations of Ibuprofen to improve its bioavailability using varied quantities of goat fat as an excipient and tween 60 as a surfactant which is a drug in the nonsteroidal anti-inflammatory drug (NSAID) class used for treating pain, fever and inflammation which is also known to be isobutylphenylpropanoic acid. The investigation proved that the formulated dosage forms showed good release profile as well as acceptable tablet properties. The batches with higher tween60: goat fat content ratios gave better release rates. The SEDDS of Ibuprofen was successfully prepared and the tablets prepared passed the various evaluation tests conducted. This method has advantage of reliance on cheap raw materials such as goat fat with fewer processing steps, best suited for lipophilic drugs where the resulting emulsification gives faster dissolution rates and absorption. Invivo evaluation of this novel dosage form is currently in progress. Self-emulsifying drug delivery systems are a promising approach for the formulation of lipophilic drug compounds having poor aqueous solubility. The oral delivery of hydrophobic drugs can be made possible by SEDDSs which have been shown to improve oral bioavailability substantially. From the formulation point of view it is necessary to consider the emulsification properties of lipid base vehicle and the solubility of drug in the lipid surfactant mixture to form a completely miscible solution so as to solubilize adequate quantities of drug in lipid vehicle. Lipids have an important role in absorption process. Thus, SEDDS plays an important role in the formulation of poorly water soluble drugs and enhancing their bioavailability.

Keywords

SEEDS, Surfactants, Tween-60, Goat Fat, Beer's Law, Lipophilic.

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Juveriya Fatima ¹, Saniya Khan ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The present article is describes a brief overview of various types of acidifiers, antacids and cathartics. For organic acids to be increasingly used in livestock feedstuffs, there is a need for an improved form: one that is less corrosive, safe, effective and easy to use. These are used for the purpose of good health.

Keywords

Acidifying Agents (dil. HCl), Acid Indigestion, Chronic, Heartburn, Inflamed Bowel, Inflammation, Cathartics Colon, Hyperosmotics, Stool, Steatorrhea.

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Rana Khan ¹, Aizaz Ahmed Khan ², Nuha Rasheed ³, Abdul Saleem Mohammad ⁴

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Engineering and Technology, Nizam Institute of Engineering and Technology, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
4 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The development of radiotraces with defined affinities for specific receptor systems is a potentially useful approach to the design of radio pharmaceuticals for nuclear medicine. Radio labeled ligands, such as hormones and neurotransmitters, are being synthesized and evaluated as diagnostic tools for diseases which can be characterized either by changes in receptor concentration or by novel receptor expression. Since the utility of a radio pharmaceutical is dependent upon the achievement of adequate ratios of target to non-target accumulation of radio activity, design of radio traces via the receptor approach attempts to exploit those systems in which receptor is present in significantly higher concentration at potential target sites such as tumors. Receptormediated radio tracers are also currently being used in animal models to investigate the normal tissue distribution of drug and hormone receptors and the in-vivo pharmacokinetics of receptor binding. The successful development of receptor-avid radiopharmaceuticals will depend upon the ability to synthesize ligands of high specific radio activity which retain the high affinity and binding specifically for the receptor after radio labeling.

Keywords

Radiopharmaceutical, Nuclear Medicine, Alpha Rays, Beta Rays, Gamma Rays, Radio Isotopes, Osteosarcoma, Therasphere, Yttrium 90, Hydroxyapatite.

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Hafsa ¹, Asfa ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

Pharmaceutical aids are the drugs and substances which have no or little pharmacological effect but they are essentially used in the preparation of pharmaceutical dosage form (like tablet, injection, emulsion, ointments etc). In this article we will be studying about the substances needed in the preparation, preservation and storage of pharmaceutical products and how are they classified into different categories and why are they necessary in preparation and does that help to the pharmacist?

Keywords

Excipient, Vehicles, Pharmacopoeia, Antiadherents, Binders, Diluents, Ingredient, Indian Pharmacopoeia, United States Pharmacopoeia, Buffering Agents, Ointments, Dosage Etc.

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Safa Mohammed Sadiq ¹, Amtul Kareem ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma.D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The treatment of microbial infection is increasingly complicated by the ability of microbe to develop resistance to antimicrobial agents. Antimicrobial agents are often categorized according to their principle mechanism of action. Mechanism includes interference with cell wall synthesis, inhibition of protein synthesis, interference with nucleic acid synthesis and disruption of bacterial membrane structure.

Keywords

Antimicrobials, Antiseptics, Disinfectants, Germicides, Bacteriostatics, Sanitizers, Oxidation, Halogenation, Protein Precipitation, Zinc Peroxide, Sodium Hypochlorite, Mild Silver Protein.

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Huda Malik ¹, Sumaiyya Sultana ¹, Nuha Rasheed ², Abdul Saleem Mohamma ³

Affiliations
1 Department of Pharma.D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

Dental hygiene has been considered as important since long. In order to maintain dental hygiene, numerous dental products are available in market. Many chemicals find use in their preparation as well as in dentistry. Although it is well known that clean teeth keeps good health and clean teeth cannot decay, it is not possible to clean the teeth continuously all the years. Numerous factors contribute to dental decay and the problem of oral hygiene arises. A large number of inorganic chemicals and their preparations are known which find application in the practice of dental and oral disorders. As they come in contact with the human body, they are regarded like other drugs and pharmaceuticals.

Keywords

Dentine, Cementum, Enamel, Decay, Dental, Disorders.

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